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SKU: E-AB-16957_200μL-ES
SMAD4 Polyclonal Antibody, 200 μL
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:0.5 mg/mL
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Calculated Molecular Weight:60 kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:60 kDa
Dilution:IHC 1:50-200
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Application:IHC
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Research Areas:Cancer;Cardiovascular;Epigenetics and Nuclear Signaling;Metabolism;Signal transduction;Stem cells
Species Reactivity:Human;Mouse;Rat
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Target Synonym:JIP;DPC4;MADH4;MYHRS
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Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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