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SKU: PKSH032418_50μg-ES
Recombinant Human CD32a/FCGR2A Protein (H131, His Tag), 50 μg
Human FcγRs are divided into three classes designated FcγRI (CD64); FcγRII (CD32); and FcγRIII (CD16); which generate multiple isoforms; are recognized. The activating- type receptor either has or associates non-covalently with an accessory subunit that has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. FcγRI binds IgG with high affinity and functions during early immune responses; whereas FcγRII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses.Human CD32; also known as Low affinity immunoglobulin γ Fc region receptor II-a (IgG Fc receptor II-a); FcγRII A or FCGR2A Protein; is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM-bearing adapter subunit; FcRγ; CD32a (FcγRII A) delivers an activating signal upon ligand binding; and results in the initiation of inflammatory responses including cytolysis; phagocytosis; degranulation; and cytokine production. The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fcγ RII B; and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Reconstitution:Please refer to the printed manual for detailed information.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
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Calculated Molecular Weight:21.1 kDa
Observed Molecular Weight:25-32 kDa
Purity: > 95 % as determined by reducing SDS-PAGE.
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Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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Calculated Molecular Weight:21.1 kDa
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Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
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Research Areas:immunology;Stem cells
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Bio-activity:Not validated for activity
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Formulation:Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
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