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SKU: PKSH030836_100μg-ES
Recombinant Human CD300a/LMIR1 Protein (Fc Tag), 100 μg
CMRF35-like molecule 8; also known as CD300 antigen-like family member A; CMRF35-H9; Immunoglobulin superfamily member 12; Inhibitory receptor protein 60; NK inhibitory receptor; CD300a and CMRF35H; is a single-pass type I membrane protein which belongs to theCD300 family. The CD300 family of myeloid immunoglobulin receptors includes activating ( CD300b; CD300e ) and inhibitory members ( CD300a; CD300f ); as well as molecules presenting a negative charge within their transmembrane domain ( CD300c; CD300d ). CD300A / IGSF12 is expressed not only by natural killer (NK) cells but also by T-cell subsets; B-cells; dendritic cells; mast cells; granulocytes and monocytes.It contains oneIg-like V-type ( immunoglobulin-like ) domain. CD300A / IGSF12 is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells; and to the down-regulation of mast cell degranulation. CD300c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells. CD300c signaling is partially mediated by a direct association with the immune receptor tyrosine-based activation motif-bearing adaptor FcεRγ. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from plasmacytoid dendritic cells (pDCs).
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Reconstitution:Please refer to the printed manual for detailed information.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
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Calculated Molecular Weight:44.5 kDa
Observed Molecular Weight:58-66 kDa
Purity: > 95 % as determined by reducing SDS-PAGE.
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Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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Calculated Molecular Weight:44.5 kDa
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Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
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Research Areas:Immunology
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Bio-activity:Not validated for activity
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Formulation:Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
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