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SKU: PKSH031822_50μg-ES
Recombinant Human Cathepsin Z Protein (His Tag), 50 μg
Cathepsin Z (CTSZ); also known as Cathepsin X or CATX; belongs to the C1 family of lysosomal cysteine proteases. Its gene structure and activity properties show several unique features that distinguish it clearly from other human cysteine proteases. It has a very short pro-region that shows no similarity to those of other cathepsins and a three-residue insertion motif that forms a characteristic ‘mini loop’. Cathepsin Z exhibits mono- and di-peptidase activity at its C-terminus; and in contrast to cathepsin B; it does not act as an endopeptidase. It is restricted to the cells of theimmune system; predominantly monocytes; macrophages and dendritic cells. Cathepsin Z is widely expressed in human tissues; suggesting that this enzyme could be involved in the normal intracellular protein degradation taking place in all cell types. It is capable to cleave regulatory motifs at C-terminus affecting the function of targeted molecules. Cathepsin X may regulate also the maturation of dendritic cells; a process; which is crucial in the initiation of adaptive immunity. Furthermore; higher levels of Cathepsin Z are also found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa; especially after infection by Helicobacter pylori. Cathepsin Z is also ubiquitously distributed in cancer cell lines and in primary tumors from different sources; suggesting that this enzyme may participate in tumor progression.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Reconstitution:Please refer to the printed manual for detailed information.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
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Calculated Molecular Weight:33 kDa
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Purity: > 97 % as determined by reducing SDS-PAGE.
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Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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Calculated Molecular Weight:33 kDa
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Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
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Application:Enzyme
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Research Areas:Tags & Cell Markers
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Bio-activity:Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK (Dnp)-OH, R&D Systems, Catalog # ES005. The specific activity is > 800 pmoles/min/μg.
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Formulation:Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
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