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SKU: E-AB-52196_200μL-ES
PRKAR2A Polyclonal Antibody, 200 μL
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Calculated Molecular Weight:46 kDa
Observed Molecular Weight:Refer to figures
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:46 kDa
Dilution:WB 1:500-1:2000;IHC 1:35-1:200
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Application:WB;IHC
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Research Areas:Cancer;Metabolism;Signal Transduction
Species Reactivity:Human
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Target Synonym:cAMP dependent protein kinase regulatory subunit alpha 2;cAMP dependent protein kinase regulatory subunit RII alpha;cAMP dependent protein kinase type II alpha regulatory chain;cAMP dependent protein kinase type II alpha regulatory subunit;cAMP-dependent protein kinase type II-alpha regulatory subunit;KAP2;KAP2;MGC3606;PKR 2;PKR2;PRKA R2;PRKAR 2;PRKAR2;PRKAR2A;Protein kinase A RII alpha subunit;Protein kinase cAMP dependent regulatory type II alpha
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Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
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Conjugation:Unconjugated
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