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SKU: E-AB-40642_25μL-ES
NF2 / Merlin Polyclonal Antibody, 25 μL
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway,a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Calculated Molecular Weight:70 kDa
Observed Molecular Weight:66-70 kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:70 kDa
Dilution:WB 1:500-1:1000
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Application:WB
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Research Areas:Cancer;Epigenetics and Nuclear Signaling;Neuroscience;Signal Transduction
Species Reactivity:Human;Mouse;Rat
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Target Synonym:ACN;BANF;Merlin;Neurofibromin 2;neurofibromin 2 (merlin);NF2;SCH;Schwannomerlin;Schwannomin
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Buffer:PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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