- Specification
- Downloads
- Reviews
$302.40
ADD TO CART
SKU: AN00472HP_100μL-ES
HRP-conjugated PCNA Monoclonal Antibody, 100 μL
Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways.Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
- Regular price
- $302.40 USD
- Sale price
- $302.40 USD
- Regular price
-
ADD TO CART
Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
Warranty:
Safety Performance:
Protection Class:
Sterile Status:
Reconstitution:
Shipping:The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Battery:
Battery Service Life:
Component:
Technical Specifications
Capacity:
Concentration:1 mg/mL
Dimension [D×W×H]:
Diameter:
Length:
Width:
High:
Volume:
Volume Range:
Speed:
Speed Range:
Max.Speed:
Max. RCF:
Temperature Range:
Operating Temperature Range:
Permissible Ambient Temperature :
Permissible Relative Humidity:
Input voltage:
Power Requirements:
Voltage/Frequency:
Sensitivity:
Specificity:
Precision:
Speed Accuracy:
Volume Accuracy:
Particle Size:
Pore Size:
Binding Capacity:
Calculated Molecular Weight:29kDa
Observed Molecular Weight:35kDa
Purity:
Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Protected from prolonged exposure to light.
Random Error:
Acceleration/Braking time:
Aspiration Speed:
Calculated Molecular Weight:29kDa
Dilution:WB 1:2500-1:5000
Driving Motor DC motor:
Em:
Ex:
Endotoxin:
Flow rate [liquid]:
Features and Capabilities
Application:WB
Detection Target:
Detection Type:
Detection Range:
Research Areas:
Species Reactivity:Human;Mouse;Rat
Reactivity:
Target Synonym:Proliferating cell nuclear antigen,PCNA,Cyclin
Test Principle:
Quantitative/Qualitative :
Result Type:
Materials :
Assay Time:
Autoclave component:
Available Rotor Adapters:
Binding Capacity:
Bio-activity:
Bottom Shape:
Bottom Type:
Buffer:PBS with 0.1% procline 300,1% protective protein and 50% glycerol,pH7.4
Cap Color:
Clonality:Monoclonal
Conjugation:HRP
Coupled Ligand:
Cover Type:
Detection Instrument :
Dispensing Speed:
Display:
Form:
Formulation:
Graduation:
Growth Area:
Powered by Bioz