SKU: AN000510P_100μg-ES

Frataxin/FXN Polyclonal Antibody, 100 μg

FXN,also named as FRDA,X25,m81-FXN,d-FXN,m78-FXN and i-FXN,belongs to the frataxin family. It promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. FXN may play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. FXN is cleaved to be 4 chains. FXN is expressed in the cytoplasm as a 210 amino acid (AA) precursor protein (pFXN; 23?KDa) that is translocated into mitochondria where it is processed by two consecutive steps into iFXN (FXN 42-210; 19?KDa) and finally mFXN (81-210; 14.2?KDa),which is functional.

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:China

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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

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Concentration:1 mg/mL

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Shelf Life:12 months

Storage:Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

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Dilution:ELISA Capture 2-8 μg/mL;ELISA Detector 0.1-0.4 μg/mL

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Application:ELISA Capture/Detector

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Research Areas:Cancer;Metabolism;Signal Transduction;Tags and Cell Markers

Species Reactivity:Human

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Target Synonym:CyaY;d-FXN;FA;FARR;Frataxin mature form;Frataxin(81-210);FRDA;FRDA;Friedreich ataxia protein;Fxn;i-FXN;m56-FXN;m78-FXN;m81-FXN;MGC57199;X25

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Buffer:Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300.

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Clonality:Polyclonal

Conjugation:Unconjugated

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