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SKU: E-AB-70144_200μL-ES
FOXO1 Polyclonal Antibody, 200 μL
FOXO1,also named as FOXO1A,FKHR and FKH1,is a member of the FOXO subfamily of Forkhead transcription factors. FOXO1 is a transcription factor which acts as a regulator of cell responses to oxidative stress. FOXO1 interacts with LRPPRC and SIRT1. In the presence of KIRT1,FOXO1 mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence. FOXO1 contains three predicted protein kinase B phosphorylation sites (Thr-24,Ser-256,and Ser-319) that are conserved in other FOXO proteins. The t(2;13) and the variant t(1;13) translocations generate PAX3/FKHR and PAX7/FKHR fusion proteins respectively. The resulting protein is a transcriptional activator. Defects in FOXO1 are a cause of rhabdomyosarcoma type 2 (RMS2).
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:320 μg/mL
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:IHC 1:300-1:1000
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Application:IHC
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Research Areas:Cancer; Epigenetics and Nuclear Signaling; Metabolism; Neuroscience; Signal Transduction
Species Reactivity:Human; Mouse; Rat
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Target Synonym:FKH 1;FKH1;FKHR;Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma);Forkhead box O1;Forkhead box protein O1;Forkhead box protein O1A;Forkhead in rhabdomyosarcoma;Forkhead;Drosophila;homolog of;in rhabdomyosarcoma;FoxO transcription factor;foxo1;FOXO1;FOXO1A;OTTHUMP00000018301
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Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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