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SKU: E-AB-F1351C_100T-ES
FITC Anti-Mouse/Rat Foxp3 Antibody[FJK-16s], 100 T
FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4 + /CD25 - cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shelf Life:12 months
Storage:This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
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Application:ICFCM
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Research Areas:Immunology
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Target Synonym:IPEXJM2ScurfinZinc finger protein JM2;Forkhead box protein P3
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Clonality:Monoclonal
Conjugation:FITC
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