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SKU: E-AB-60232_60μL-ES
FEN1 Polyclonal Antibody, 60 μL
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1mg/mL
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Calculated Molecular Weight:35kDa/42kDa
Observed Molecular Weight:48kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:35kDa/42kDa
Dilution:WB 1:500-1:2000;IHC 1:50-1:200;IF 1:10-1:100
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Application:WB;IHC;IF
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Research Areas:Cancer;Epigenetics and Nuclear Signaling
Species Reactivity:Human;Mouse
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Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Clonality:Polyclonal
Conjugation:Unconjugated
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