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SKU: E-AB-14995_60μL-ES
ERCC6L Polyclonal Antibody, 60 μL
PICH (Plk1-interacting checkpoint helicase), also known as DNA excision repair protein ERCC-6-like (ERCC6L) or tumor antigen BJ-HCC-15, is a 1,250 amino acid protein belonging to the SNF2/RAD54 helicase family. PICH is a DNA helicase and an essential component of the spindle assembly checkpoint. During mitosis, PICH recruits MAD2 to kinetochores and also regulates the tension on centromic chromatin. PICH is concentrated in between the kinetochores in prometophase cells, while in metaphase it localizes to the thin threads composed of catenated centromeric DNA that stretch between sister kinetochores. PICH is phosphorylated by Plk, which prevents PICH from associating with chromosome arms and restricts the localization of PICH to the kinetochore-centromere region. PICH/Plk interaction is also required for correct Plk localization to the kinetochore. PICH contains one helicase ATP-binding domain, two TPR repeats and one helicase C-terminal domain.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:0.5 mg/mL
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:IHC 1:50-1:200
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Application:IHC
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Research Areas:Cell Biology;Epigenetics and Nuclear Signaling
Species Reactivity:Human
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Target Synonym:ATP dependent helicase ERCC6 like;ATP-dependent helicase ERCC6-like;DNA excision repair protein ERCC 6 like;DNA excision repair protein ERCC-6-like;ERC6L;ERCC 6L;Ercc6l;Excision repair cross complementing rodent repair deficiency complementation group 6 like;Excision repair protein ERCC6 like;FLJ20105;MGC131695;PICH;Plk1 interacting checkpoint helicase;PLK1-interacting checkpoint helicase;SNF2/RAD54 family protein;Tumor antigen BJ HCC 15;Tumor antigen BJ-HCC-15
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Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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