SKU: E-AB-68326_60μL-ES

DMP1 Polyclonal Antibody, 60 μL

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:China

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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

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Concentration:1 mg/mL

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Calculated Molecular Weight:54kDa/55kDa

Observed Molecular Weight:102KDa

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Shelf Life:12 months

Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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Calculated Molecular Weight:54kDa/55kDa

Dilution:WB 1:500-1:2000

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Application:WB

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Research Areas:Signal Transduction; Stem Cells; Developmental Biology

Species Reactivity:Human; Mouse; Rat

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Target Synonym:DMP1;ARHP;ARHR;DMP-1

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Buffer:PBS with 0.05% proclin300,50% glycerol,pH7.3.

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Clonality:Polyclonal

Conjugation:Unconjugated

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