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SKU: E-AB-11148_60μL-ES
DDIT4 Polyclonal Antibody, 60 μL
REDD-1, also designated DNA-damage-inducible transcript 4, dig2 or RTP801, is thought to function in the regulation of reactive oxygen species (ROS). REDD-1 expression has also been linked to apoptosis, Ab toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level. REDD-1 negatively regulates the mammalian target of Rapamycin (mTOR), a serine/threonine kinase often referred to as FRAP. It is crucial in the coupling of extra- and intracellular cues to FRAP regulation. The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:0.8 mg/mL
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:IHC 1:50-1:200
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Application:IHC
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Research Areas:Cancer;Cardiovascular;Epigenetics and Nuclear Signaling;Metabolism
Species Reactivity:Human;Mouse;Rat
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Target Synonym:DDIT4;DDIT4;Dig2;DNA damage inducible transcript 4;DNA damage inducible transcript 4 protein;DNA damage-inducible transcript 4 protein;FLJ20500;HIF 1 responsive protein RTP801;HIF 1 responsive RTP801;HIF-1 responsive protein RTP801;Protein regulated in development and DNA damage response 1;REDD-1;REDD1;RTP801
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Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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