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SKU: E-AB-52070_120μL-ES
CREBBP Polyclonal Antibody, 120 μL
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:IHC 1:30-1:150
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Application:IHC
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Research Areas:Cancer;Epigenetics and Nuclear Signaling;Metabolism;Microbiology;Stem Cells
Species Reactivity:Human;Mouse;Rat
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Target Synonym:CBP;CBP;CREB binding protein;CREB-binding protein;Crebbp;Cyclic AMP responsive enhancer binding protein;KAT3A;RSTS;RTS;Rubinstein Taybi syndrome
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Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
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Conjugation:Unconjugated
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