Elabscience

庫存單位: E-AB-52062_20μL-ES

ZBTB33多克隆抗體，20 μL

此基因編碼具有雙峰 DNA 結合特異性的轉錄調節因子，可與甲基化的 CGCG 結合，也可與非甲基化的一致 KAISO 結合位點 TCCTGCNA 結合。此蛋白質含有 N 端 POZ/BTB 結構域和 3 個 C 端鋅指基序。它招募 N-CoR 阻遏物複合物來促進組蛋白去乙醯化和目標基因啟動子中抑制性染色質結構的形成。它可能有助於抑制 Wnt 訊號通路的目標基因，也可能透過募集 catenin delta-2 (CTNND2) 來活化一組目標基因的轉錄。它與 catenin delta-1 (CTNND1) 的相互作用抑制了與甲基化和非甲基化 DNA 的結合。它也直接與核輸入受體 Importin-α2（也稱為核轉運蛋白 alpha2 或 RAG 隊列 1）相互作用，從而介導這種蛋白質的核輸入。編碼相同蛋白質的剪接轉錄變異體已被鑑定。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Dilution:免疫組化 1:40-1:200

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Application:免疫組織化學

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Research Areas:癌症；表觀遺傳學和核子訊號傳導

Species Reactivity:人類

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Target Synonym:Kaiso;Kaiso 蛋白;Kaiso 轉錄因子;KAISO;轉錄調節因子 Kaiso;ZBTB 33;Zbtb33;含鋅指和 BTB 結構域的 33;含鋅指和 BTB 結構域的蛋白 33;鋅指轉錄因子 Kaiso;ZNF 348;ZNF Kai Kai;ZNF348

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Buffer:含 0.05% NaN3 和 40% 甘油的 PBS，pH7.4

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