Elabscience

庫存單位: AN000820P_25μg-ES

TNF RI/TNFRSF1A 多克隆抗體（捕獲/檢測），25 μg

腫瘤壞死因子（TNF）是一種多功能細胞因子，在調節發炎、免疫功能、宿主防禦和細胞凋亡中起關鍵作用。 TNF 以可溶性及膜結合形式存在。 TNF 透過兩種不同的細胞表面受體 TNFR1 (TNFRSF1A、CD120a) 和 TNFR2 (TNFRSF1B、CD120b) 發出訊號。 TNFR1 廣泛表達，而 TNFR2 的表達僅限於免疫系統細胞、內皮細胞和神經細胞。 TNFR1 在其胞質內區域內含有死亡結構域 (DD)，被認為是 TNF 訊號傳導的關鍵受體。此受體可活化NF-κB，介導細胞凋亡，並發揮發炎調節作用。抗凋亡蛋白BCL2相關的凋亡基因4（BAG4/SODD）以及銜接蛋白TRADD和TRAF2已被證明能與此受體相互作用，在受體介導的訊號傳導中發揮調節作用。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Concentration:1毫克/毫升

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Shelf Life:12個月

Storage:4°C 下儲存有效期限為 12 個月，-20°C 下儲存有效期限為長期儲存，避免凍融循環。

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Dilution:ELISA 捕捉 2-8 μg/mL；ELISA 檢測 0.1-0.4 μg/mL

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Application:ELISA 擷取/檢測儀

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Research Areas:癌症；細胞生物學；心血管；免疫學；訊號傳導；幹細胞

Species Reactivity:人類

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Target Synonym:TNF-R;TNF-RI;TNF-R55;TNFAR;TNFR1;TNFR1-d2;TNFR55;TNFR60;p55;p55-R;p60;CD120a;FPF;MS5;TBP1;

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Buffer:磷酸鹽緩衝溶液，pH 值為 7.2，含 0.05% proclin 300。

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Clonality:多克隆

Conjugation:未結合

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