Elabscience

庫存單位: E-AB-52933_20μL-ES

SETDB1多株抗體，20 μL

SETDB1，又稱為ESET、KIAA0067和KMT1E，屬於組蛋白賴氨酸甲基轉移酶家族。它是一種具有組蛋白 H3-K9 特異性甲基轉移酶活性的 SET 結構域蛋白。 H3 'Lys-9' 三甲基化與 DNA 甲基化相協調，並透過募集 HP1（CBX1、CBX3 和/或 CBX5）蛋白至甲基化組蛋白來代表表觀遺傳轉錄抑制的特定標籤。 SETDB1主要在真染色質區域發揮作用，從而在真染色質基因沉默中扮演核心角色。它可能與 MBD1 和 ATF7IP 形成複合物，抑制轉錄並將 DNA 甲基化和組蛋白「Lys-9」三甲基化偶聯。其活性依賴MBD1，並透過CAF-1招募而透過DNA複製遺傳地維持。 SETDB1 調節組蛋白甲基化、基因沉默性和轉錄抑制。由於基因沉默和轉錄功能障礙可能在疾病發病機制中發揮作用，它已被確定為亨廷頓舞蹈症的治療目標。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Dilution:免疫組化 1:50-1:300

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Application:免疫組織化學

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Research Areas:癌症；表觀遺傳學和核子訊號傳導

Species Reactivity:人;小鼠

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Target Synonym:AU022152；EC 2.1.1.43；帶有 SET 結構域的 ERG 相關蛋白；ESET；H3 K9 HMTase 4；H3-K9-HMTase 4；H3-K9-HMTase4；組蛋白 H3 K9 甲基轉移酶 4；組蛋白 H3-K9 甲基轉移酶； KMT1E；賴氨酸 N-甲基轉移酶 1E；MGC90670；mKIAA0067；SET 結構域分叉 1；Set 結構域蛋白；分叉；1；SETB1；Setdb1

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Buffer:含 0.05% NaN3 和 40% 甘油的 PBS，pH7.4

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