Elabscience

庫存單位: E-AB-18284_20μL-ES

RIPK1多克隆抗體，20 μL

絲胺酸-蘇胺酸激酶在死亡受體連接、病原體識別受體 (PRR) 活化和 DNA 損傷後傳遞發炎和細胞死亡訊號（程序性壞死）。當 TNF-alpha 家族細胞激素活化 TNFR1 時，TRADD 和 TRAF2 被募集到受體上。以 TNF-alpha 依賴的方式在「Ser-728」處磷酸化 DAB2IP，進而活化 MAP3K5-JNK 凋亡級聯。 TRAF2 透過「Lys-63」連接鏈進行泛素化，可增強與絲裂原活化蛋白激酶途徑和 NF-κB 途徑中下游訊號轉導子的通訊，進而介導下游事件，包括活化編碼發炎分子的基因。多泛素化蛋白與 IKBKG/NEMO（IKK 複合物的調節亞基）結合，這是 NF-kappa-B 活化的關鍵事件。與其他含有 RHIM 的細胞適配器的相互作用會引發基因活化和細胞死亡。特別是 RIPK1 和 RIPK3 結合形成壞死誘導複合物。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Concentration:0.7 毫克/毫升

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Calculated Molecular Weight:76千道爾頓

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Calculated Molecular Weight:76千道爾頓

Dilution:免疫印跡法 1:500-1:2000

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Application:免疫組化

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Research Areas:癌症；細胞生物學；訊號傳導

Species Reactivity:人類

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Target Synonym:細胞死亡蛋白RIP；FLJ39204；OTTHUMP00000039163；受體（TNFRSF）相互作用絲氨酸蘇氨酸激酶1；受體相互作用蛋白1；受體相互作用蛋白；受體相互作用蛋白激酶1；受體相互作用絲氨酸蘇氨酸蛋白激酶1；受體TNFRSFSFRIP1；RIP 1；克1；RIPK1；絲胺酸蘇胺酸蛋白激酶RIP；絲胺酸/蘇胺酸蛋白激酶 RIP

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Buffer:含 0.05% NaN3 和 40% 甘油的 PBS，pH7.4

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Clonality:多克隆

Conjugation:未結合

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