庫存單位: PKSH030364_50μg-ES

重組人 TAOK3/JIK/MAP3K18 蛋白 (aa 1-411, His & GST 標籤), 50 μg

絲胺酸/蘇胺酸蛋白激酶TAO3,又稱為皮膚T細胞淋巴瘤相關抗原HD-CL-09、CTCL相關抗原HD-CL-09、樹突狀細胞衍生蛋白激酶、JNK/SAPK抑制激酶、Jun激酶抑制激酶、雞同源物A激酶、一千零一氨基酸蛋白3、JIK、TAK3和MAP3K18,是屬於亞氏蛋白激酶、STE、STE、STE、STE、STE、STE、STE」家族的亞氏蛋白家族。蛋白激酶是細胞訊號傳導的關鍵調節劑,透過位點特異性磷酸化事件調節彼此的功能和活動。 TAOK3/JIK含有一個蛋白激酶結構域。 TAOK3/JIK在體內普遍存在低水平表達,在周邊血液白血球(PBL)、胸腺、脾臟、腎臟、骨骼肌、心臟和肝臟中高表達。 TAOK3 / JIK 抑制Jun激酶的基礎活性。它受到表皮生長因子(EGF)的負面調節。當過度表現時,TAOK3/JIK 可能會活化 ERK1/ERK2 和 JNK/SAPK。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Reconstitution:不適用

Shipping:本產品以液體形式提供。它是在冷凍溫度下用藍冰/凝膠包運輸的。收到後,立即存放在<-20°C的環境中。

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Calculated Molecular Weight:74.3 kDa

Observed Molecular Weight:85千道爾頓

Purity: 以還原 SDS-PAGE 測定,結果為 > 92%。

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Storage:儲存溫度<-20°C,可穩定保存6個月。請盡量減少凍融循環。

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Calculated Molecular Weight:74.3 kDa

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Endotoxin: 經 LAL 方法測定,每 μg 蛋白質含量 < 1.0 EU。

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Application:酵素

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Research Areas:訊號傳導、表觀遺傳學和核子訊號傳導

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Bio-activity:使用合成的 PKCtide 勝肽 (ERMRPRKRQGSVRRRV) 作為底物,確定比活性為 10 nmol/min/mg。

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Formulation:以 20mM Tris、500mM NaCl、3mM GSH、pH 7.4、10% 甘油的無菌溶液形式提供

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