Elabscience

庫存單位: PKSH030329_50μg-ES

重組人 PFK2/PFKFB3 蛋白 (His & GST 標籤), 50 μg

果糖-2,6-雙磷酸酶 3，也稱為 6-磷酸果糖-2-激酶或 PFK2 或 PFKFB3，是磷酸果糖激酶的有效活化劑，而磷酸果糖激酶是糖解作用的限速酵素。在人類腫瘤細胞、血管內皮細胞和平滑肌細胞中發現高度磷酸化的PFKFB3蛋白。果糖 2,6-雙磷酸 (Fru-2,6-BP) 是 6-磷酸果糖-1-激酶 (PFK-1) 的變構活化劑，PFK-1 是糖解作用中的限速酵素和重要控制點。 PFK2 的濃度取決於雙功能酵素 6-磷酸果糖-2-激酶/果糖-2,6-雙磷酸酶 (PFK-2/FBPase) 的活性。 PFK2 透過變構活化劑果糖 2,6-雙磷酸控製糖解通量。由於其原癌特性，PFKFB3 基因的 PFK-2/FBPase-2 被認為在腫瘤發生中起關鍵作用。 6-磷酸果糖-2-激酶/果糖-2,6-雙磷酸酶 (PFKFB3) 的缺氧誘導形式即使在嚴重缺氧條件下也能啟動癌細胞的糖解途徑，從而在癌細胞的進展中發揮關鍵作用。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Reconstitution:不適用

Shipping:本產品以液體形式提供。它是在冷凍溫度下用藍冰/凝膠包運輸的。收到後，立即存放在<-20°C的環境中。

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Calculated Molecular Weight:87.4 kDa

Observed Molecular Weight:75千道爾頓

Purity: 以還原 SDS-PAGE 測定，結果為 > 85%。

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Storage:儲存溫度<-20°C，可穩定保存6個月。請盡量減少凍融循環。

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Calculated Molecular Weight:87.4 kDa

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Endotoxin: 經 LAL 方法測定，每 μg 蛋白質含量 < 1.0 EU。

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Research Areas:心血管、訊號傳導、神經科學、癌症、代謝

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Bio-activity:未驗證活動

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Formulation:以 20mM Tris、500mM NaCl、pH 7.0、10% 甘油、0.3mM DTT 的無菌溶液形式提供

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