Elabscience

庫存單位: PKSH032747_10μg-ES

重組人間皮素/MSLN 蛋白 (aa 37-286, Fc 標籤), 10 μg

間皮素是一種細胞表面糖蛋白，其表達僅限於漿膜（胸膜、心包膜和腹膜）的間皮細胞和氣管的上皮細胞；扁桃體；輸卵管；和腎臟。間皮素在細胞存活中扮演重要角色；增殖;移民；入侵；腫瘤進展；以及對化療的抵抗力。間皮素的過度表現可以活化NF-κB和訊號傳導和轉錄活化因子3（Stat3）；抑制細胞凋亡訊號和 TNF-α 誘導的細胞凋亡；並加速G1–S轉型。間皮素在各種癌症中也被發現過度表達；包括惡性間皮瘤；胰腺癌或卵巢癌；肉瘤和一些胃腸道癌症或肺癌。由於其在正常組織中的表現有限；據報道，間皮素是開發標靶治療的理想腫瘤相關標記。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Reconstitution:請參閱印刷手冊以取得詳細資訊。

Shipping:本產品以凍乾粉形式提供，並附冰袋運送。

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Calculated Molecular Weight:53.9 kDa

Observed Molecular Weight:55-75 kDa

Purity: 以還原 SDS-PAGE 測定，結果為 > 90%。

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Storage:一般來說，冷凍乾燥蛋白在-20至-80℃保存可穩定保存長達12個月。重建後的蛋白溶液可在4-8℃保存2-7天。重建樣品的等分試樣在 < -20℃ 穩定保存 3 個月。

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Calculated Molecular Weight:53.9 kDa

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Endotoxin: 經 LAL 方法測定，每 μg 蛋白質含量 < 1.0 EU。

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Research Areas:標籤和細胞標記；癌症；免疫學

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Bio-activity:未驗證活動

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Formulation:從 0.2 μm 過濾的 PBS 溶液（pH 7.4）中冷凍乾燥。
通常在冷凍乾燥前會添加5%～8%的海藻糖、甘露醇和0.01%的吐溫80作為保護劑。
請參閱印刷手冊中的具體緩衝液資訊。

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