庫存單位: PKSH030318_50μg-ES

重組人類 ERK3/MAPK12 蛋白 (His & GST 標籤), 50 μg

ERK3;也稱為 MAPK12 和 p38-gamma;屬於蛋白激酶超家族; CMGC Ser/Thr 蛋白激酶家族和 MAP 激酶亞家族。 ERK3 在骨骼肌和心臟中高度表現。 ERK3 是一種絲胺酸/蘇胺酸激酶,是 MAP 激酶訊號傳導路徑的重要組成部分。 MAPK12 是四種 p38 MAPK 之一,在細胞外刺激(例如促炎細胞因子或物理壓力)引起的細胞反應級聯中發揮重要作用,從而直接激活轉錄因子(例如 ELK1 和 ATF2)。因此; p38 MAPK 會磷酸化多種蛋白質,據估計每種蛋白質可能有大約 200 到 300 種底物。 MAPK12 是 PLK1 正常動粒定位所必需的;防止染色體不穩定並支持有絲分裂細胞活力。 MAPK12 訊號也在肌肉生長和再生過程中積極調節瞬時擴增成肌前驅細胞的擴增。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Reconstitution:不適用

Shipping:本產品以液體形式提供。它是在冷凍溫度下用藍冰/凝膠包運輸的。收到後,立即存放在<-20°C的環境中。

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Calculated Molecular Weight:69.8 kDa

Observed Molecular Weight:65千道爾頓

Purity: 以還原 SDS-PAGE 測定,結果 > 95%。

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Storage:儲存溫度<-20°C,可穩定保存6個月。請盡量減少凍融循環。

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Calculated Molecular Weight:69.8 kDa

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Endotoxin: 經 LAL 方法測定,每 μg 蛋白質含量 < 1.0 EU。

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Research Areas:訊號傳導;細胞生物學;

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Bio-activity:未驗證活動

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Formulation:以 20mM Tris、500mM NaCl、10% 甘油、pH 8.0 的無菌溶液形式提供

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