Elabscience

庫存單位: PKSH030428_50μg-ES

重組人 EGFR/ErbB1 蛋白 (aa 668-1210, His&GST 標籤), 50 μg

作為表皮生長因子受體（EGFR）家族的成員； EGFR 蛋白是 I 型跨膜糖蛋白，可結合 EGF 家族配體子集，包括 EGF；雙調蛋白；轉化生長因子-α； β-纖維素； EGFR蛋白在調控細胞增殖的信號通路中起著至關重要的作用；生存和分化。配體結合誘導 EGFR 蛋白同源或異源二聚化；隨後的酪胺酸自身磷酸化並啟動各種下游路徑 (MAPK；PI3K/PKB 和 STAT)。此外; EGFR訊號傳導也被證明對致癌作用和疾病進展起作用；因此EGFR蛋白目前被提出作為癌症治療的標靶。

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Product Specification

Basic Information

Brands:Elabscience

Model Number:

Place of Origin:中國

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Sterile Status:

Reconstitution:不適用

Shipping:本產品以液體形式提供。它是在冷凍溫度下用藍冰/凝膠包運輸的。收到後，立即存放在<-20°C的環境中。

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Calculated Molecular Weight:89.1 kDa

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Purity: 以還原 SDS-PAGE 測定，結果為 > 85%。

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Storage:儲存溫度<-20°C，可穩定保存6個月。請盡量減少凍融循環。

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Calculated Molecular Weight:89.1 kDa

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Endotoxin: 經 LAL 方法測定，每 μg 蛋白質含量 < 1.0 EU。

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Application:酵素

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Research Areas:訊號傳導；癌症；

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Bio-activity:使用聚（Glu：Tyr）4：1為底物，測定比活性為105 nmol/min/mg。

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Formulation:以 20 mM Tris、500 mM NaCl、10% 甘油（pH 7.4）的無菌溶液形式提供

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