Elabscience

庫存單位: E-AB-81546_100μL-ES

重組Chk2單株抗體，100μL

為了應對 DNA 損傷和複製阻滯，細胞週期進程透過關鍵細胞週期調節劑的控製而停止。此基因編碼的蛋白質是細胞週期檢查點調節劑和假設的腫瘤抑制因子。它含有一個叉頭相關蛋白相互作用結構域，該結構域對於響應 DNA 損傷而激活至關重要，並且在複製阻滯和 DNA 損傷後迅速被磷酸化。當被活化時，編碼的蛋白質會抑制 CDC25C 磷酸酶，阻止進入有絲分裂，並已被證明可以穩定腫瘤抑制蛋白 p53，導致細胞週期停滯在 G1。此外，該蛋白質與BRCA1相互作用並對其進行磷酸化，使得BRCA1在DNA損傷後恢復存活。該基因的突變與李-法美尼症候群有關，這是一種高度滲透的家族性癌症表型，通常與 TP53 的遺傳突變有關。此外，該基因的突變被認為會導致肉瘤、乳癌和腦瘤的易感性。此核蛋白是絲胺酸/蘇胺酸蛋白激酶 CDS1 亞家族的成員。已發現該基因有幾種編碼不同異構體的轉錄變異。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Concentration:300微克/毫升

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Calculated Molecular Weight:61kDa

Observed Molecular Weight:61kDa

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Calculated Molecular Weight:61kDa

Dilution:廣譜 1:500-1:1000

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Application:世界銀行

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Research Areas:癌症;表觀遺傳學和核子訊號

Species Reactivity:人類

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Target Synonym:CDS 1;Cds1;Cds1 同源物;檢查點激酶 2;檢查點樣蛋白 CHK2;CHEK 2;Chek2;Chk 2;​​CHK2 檢查點同源物 (S. pombe);CHK2 檢查點同源物;CHK2;hCds1;HuC45;激酶 Chk2;絲胺酸/蘇胺酸蛋白激酶 Chk2

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Buffer:50mM Tris-Glycine（pH 7.4）、0.15M NaCl、40% 甘油、0.01% 疊氮化鈉和 0.05% 保護蛋白

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Clonality:兔單克隆

Conjugation:未結合

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