Elabscience

庫存單位: E-AB-52172_200μL-ES

PPM1D多株抗體，200 μL

此基因編碼的蛋白質是 PP2C 家族 Ser/Thr 蛋白磷酸酶的成員。已知 PP2C 家族成員是細胞壓力反應途徑的負調節因子。該基因的表達以 p53 依賴的方式誘導，以響應各種環境壓力。此磷酸酶在腫瘤抑制蛋白TP53/p53誘導時，負調控p38 MAP激酶MAPK/p38的活性，進而降低p53的磷酸化，進而抑制p53介導的轉錄及細胞凋亡。因此，這種磷酸酶介導 p38-p53 訊號的回饋調節，有助於抑制生長和抑制壓力誘導的細胞凋亡。該基因位於已知在乳癌中被擴增的染色體區域。在乳癌細胞系和原發性乳腺腫瘤中均檢測到了該基因的擴增，這表明該基因在癌症發展中發揮作用。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Dilution:免疫組化 1:50-1:300

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Application:免疫組織化學

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Research Areas:癌症；訊號傳導

Species Reactivity:人;小鼠

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Target Synonym:EC 3.1.3.16；p53 誘導的蛋白磷酸酶 1；p53 誘導的蛋白磷酸酶 1；PP2C delta；PP2C-delta；PP2CD；Ppm1d；PPM1D；蛋白磷酸酶 1D；蛋白磷酸酶 1D 鎂依賴性 delta 蛋白異構體；PPM1D；蛋白磷酸酶 1D；蛋白磷酸酶 1D 鎂依賴性 delta 蛋白異構體；鎂依賴性 1 delta；蛋白磷酸酶 Mg2+/Mn2+ 依賴性 1D；蛋白磷酸酶 Wip1；野生型 p53 誘導的磷酸酶 1；WIP 1；WIP1

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Buffer:含 0.05% NaN3 和 40% 甘油的 PBS，pH7.4

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