Elabscience

庫存單位: E-AB-52809_60μL-ES

PNRC2 多株抗體，60 μL

透過充當 mRNA 脫帽複合物和 NMD 機制之間的橋樑，參與無義介導的 mRNA 衰變 (NMD) (PubMed：19150429)。可能透過將 NMD 機制定位到 P 體並將脫帽機制募集到異常 mRNA 上來發揮作用（PubMed：19150429）。 UPF1/RENT1 定位至 P 體所需（PubMed：19150429）。當它與目標 mRNA 的 5' UTR 結合時，透過以配體依賴的方式與糖皮質激素受體 NR3C1 相互作用並募集 RNA 解旋酶 UPF1 和 mRNA 脫帽酶 DCP1A，導致 RNA 衰變，從而在糖皮質激素受體介導的 mRNA 降解中發揮作用（PubMed：25775514）。也可作為核受體輔激活劑（PubMed：11574675）。可能在控制能量儲存和能量消耗之間的能量平衡方面發揮作用（透過相似性）。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Dilution:免疫組化 1:50-1:300

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Application:免疫組織化學

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Research Areas:表觀遺傳學和核子訊號

Species Reactivity:人類;小鼠;大鼠

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Target Synonym:0610011E17Rik；D4Bwg0593e；FLJ20312；MGC11707；MGC93828；MGC99541；OTTMUSP00000010360；OTTMUSP00000010366； 1-4M23.5；RP23-161N17.3

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Buffer:含 0.05% NaN3 和 40% 甘油的 PBS，pH7.4

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