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庫存單位: E-AB-51043_60μL-ES
磷酸化 SMAD3 (Ser425) 單株抗體，60 μL
受體調節的 SMAD (R-SMAD) 是一種由 TGF-β（轉化生長因子）和活化素 1 型受體激酶活化的細胞內訊號傳導和轉錄調節劑。與 TGF-beta 調控的許多基因啟動子區的 TRE 元素結合，並在 SMAD3/SMAD4 複合物形成後活化轉錄。也可以在 AP-1/SMAD 位點形成 SMAD3/SMAD4/JUN/FOS 複合物來調節 TGF-β 介導的轉錄。可能透過調節原代角質形成細胞的生長和遷移以及改變 TGF 介導的單核細胞趨化作用，對傷口癒合產生抑製作用。這種對傷口癒合的影響似乎是荷爾蒙敏感的。調節軟骨形成和成骨作用並抑制骨折的早期癒合。透過刺激 PDPK1 激酶活性與 14-3-3 蛋白 YWHAQ 分離來正向調節 PDPK1 激酶活性，而 14-3-3 蛋白 YWHAQ 則起著負調節劑的作用。
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:中國
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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。
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Shelf Life:12個月
Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。
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Dilution:免疫組化 1:50-300
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Application:免疫組化
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Research Areas:癌症；表觀遺傳學和核子訊號；代謝；訊號傳導；幹細胞
Species Reactivity:人類;小鼠;大鼠
Reactivity:
Target Synonym:DKFZP586N0721；DKFZp686J10186；hMAD 3；hMAD-3；hSMAD3；HSPC193；HST17436；JV15 2；JV15-2；JV152；LDS1C；LDS3；DDomic)；同源物 JV15 2；Mad 蛋白質同源物；MAD；mothers against decapentaplegic 同源物 3；Mad3；MADH 3；MADH3；MGC60396；Mothers against decapentaplegic 同源物 3；Mothers against DPP 同源蛋白 3；DSMA MADD SMAD4SMA 4PSMA 4PSMA 4SMA； 3；SMAD；mothers against DPP 同源物 3；Smad3；SMAD3
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Buffer:含有 0.02% 疊氮化鈉和 50% 甘油的 PBS，pH 值為 7.4。
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Conjugation:未結合
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