Elabscience

庫存單位: E-AB-20802_120μL-ES

磷酸化 Pan-Akt (Ser473) 多克隆抗體，120 μL

作為 AKT-mTOR 訊號通路的關鍵調節劑發揮作用，控製成人神經發生過程中新生神經元整合過程的節奏，包括正確的神經元定位、樹突發育和突觸形成（透過相似性）。通用蛋白激酶，能夠磷酸化多種已知蛋白質。磷酸化 TBC1D4。磷脂酰肌醇 3-激酶 (PI(3)K) 下游的信號介導各種生長因子的作用，例如血小板衍生的生長因子 (PDGF)、表皮生長因子 (EGF)、胰島素和胰島素樣生長因子 I (IGF-I)。透過介導胰島素誘導的 GLUT4 葡萄糖轉運蛋白向細胞表面的易位，在葡萄糖轉運中發揮作用。介導 IGF-I 的抗凋亡作用。透過在「Ser-939」和「Thr-1462」處磷酸化 TSC2 來介導胰島素刺激的蛋白質合成，從而激活 mTORC1 信號傳導並導致 4E-BP1 磷酸化和 RPS6KB1 活化。透過介導胰島素誘導的糖原合成酶活化來促進糖原合成。活化形式可以抑制FoxO基因轉錄並促進細胞週期進程。對於 SPATA13 介導的細胞遷移和黏附組裝和拆卸的調節至關重要。

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Product Specification

Basic Information

Brands:Elabscience

Model Number:

Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Concentration:1毫克/毫升

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Calculated Molecular Weight:56kDa

Observed Molecular Weight:55kDa

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Calculated Molecular Weight:56kDa

Dilution:WB 1:500-1:2000；IHC 1:100-1:300；IF 1:50-1:200

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Application:WB;IHC-p;IF

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Research Areas:癌症；神經科學；訊號傳導

Species Reactivity:人類;小鼠;大鼠

Reactivity:

Target Synonym:AKT1；PKB；RAC；RAC-alpha 絲氨酸/蘇氨酸蛋白激酶；蛋白激酶 B；PKB；蛋白激酶 B alpha；PKB alpha；原癌基因 c-Akt；RAC-PK-alpha；AKT2；RAC-beta 絲氨酸/蘇氨酸蛋白激酶；蛋白激酶 Akt-2；蛋白激酶 B

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Buffer:含0.02％疊氮化鈉、0.5％保護蛋白和50％甘油的PBS，pH7.4

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Clonality:多克隆

Conjugation:未結合

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