庫存單位: E-AB-F1135UD_100μg-ES

PE抗鼠CD206/MMR抗體[C068C2],100μg

CD206,也稱為甘露糖受體(MR),是一種 175 kD I 型膜蛋白。它是一種屬於C型凝集素超家族的模式辨識受體(PRR)。 MR 在巨噬細胞、樹突狀細胞、朗格漢斯細胞以及肝臟或淋巴管內皮細胞上表現。 MR 透過其 C 型凝集素樣碳水化合物識別域識別一系列帶有甘露糖、岩藻糖或 N-乙醯葡萄糖胺的微生物碳水化合物,透過其富含半胱氨酸的結構域識別硫酸化碳水化合物抗原,並透過其纖維連接蛋白 II 型結構域識別膠原蛋白。 MR 介導內吞作用和吞噬作用以及巨噬細胞的活化和抗原呈現。它在宿主防禦中發揮重要作用,並充當先天免疫和適應性免疫之間的紐帶。最近,發現淋巴管內皮細胞上的 MR 參與白血球運輸並且是癌細胞轉移行為的因素之一。這表明,MR 可能透過靶向淋巴管成為控制發炎和癌症轉移的潛在標靶。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Concentration:0.2毫克/毫升

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Shelf Life:12個月

Storage:本品在2-8℃下可保存12個月。請避免長時間暴露在光線下並且不要冷凍。

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Application:流式細胞儀

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Research Areas:細胞生物學;免疫學;先天免疫;訊號傳導

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Target Synonym:MMR;MR;MRC1;巨噬細胞甘露糖受體;甘露糖受體

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