Elabscience

庫存單位: D-AB-10399L_25μL-ES

MMP-2多株抗體，25 μL

基質金屬蛋白酶2（MMP-2）是一種降解細胞外基質成分的酶，因此在生理和病理過程中的細胞遷移中起關鍵作用。 MMP-2的表達依賴於細胞外基質金屬蛋白酶誘導劑（EMMPRIN）、Her2/neu、生長因子、細胞激素和激素。 Pro-MMP-2的活化需要MT1-MMP和TIMP-2的參與。單側耳蝸消融後MMP-2在耳蝸腹側核的分佈改變,含量增加。低水平的MMP-2與荷爾蒙受體陰性腫瘤患者的預後良好有關，而荷爾蒙受體陰性腫瘤通常具有高風險。 MMP-2作為一種需要蛋白水解活化才能發揮催化活性的酶原，廣泛參與許多癌症模型系統的侵襲和轉移，包括人類乳癌（HBC）。在乳癌發展過程中阻斷 MMP-2 的分泌和活化可能會減少轉移。單獨檢測活性MMP-2或pro-MMP-2與活性MMP-2的比率被認為是癌症轉移的非常敏感的指標。因此，透過特定的抑制劑和活化劑調節 MMP-2 的表達和活化可能為乳癌治療提供一種新的機制。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Concentration:1毫克/毫升

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Calculated Molecular Weight:74kDa

Observed Molecular Weight:69kDa-72kDa

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Calculated Molecular Weight:74kDa

Dilution:廣譜 1:500-1:1000

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Application:世界銀行

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Research Areas:癌症；細胞生物學；心血管；代謝

Species Reactivity:小鼠;大鼠

Reactivity:

Target Synonym:72 kDa IV 型膠原蛋白酶；72 kDa 明膠酶；明膠酶 A；基質金屬蛋白酶-2；MMP-2；TBE-1；MMP2；CLG4A；CLG4；MMP-II；MONA；TBE-1

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Buffer:含0.02％疊氮化鈉、1％保護蛋白和50％甘油的PBS，pH7.4

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Conjugation:未結合

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