Elabscience

庫存單位: E-AB-70262_200μL-ES

MGMT多株抗體，200 μL

MGMT（O6-甲基鳥嘌呤-DNA甲基轉移酶）在DNA損傷後被轉錄激活，並起到修復致癌物或細胞抑制藥物引起的誘變和細胞毒性O6-烷基鳥嘌呤損傷的作用。在缺乏 p53 的小鼠中，電離輻射不會誘導 MGMT，這表明 MGMT 誘導可能需要 p53。類似地，MGMT mRNA 和蛋白質被證明只能在表達功能性 p53 的細胞系中被電離輻射誘導，而在不表達野生型 p53 的細胞系中則不能。相反，在一項針對口腔癌細胞系的研究中，高 MGMT 活性與突變 p53 的存在有關。類似地，野生型 p53 的卵巢腫瘤中 MGMT 活性明顯低於突變型 p53 的卵巢腫瘤中 MGMT 活性，支持野生型 p53 下調基礎 MGMT 啟動子的觀點。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Concentration:260微克/毫升

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Dilution:免疫組化 1:100-1:500

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Application:免疫組織化學

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Research Areas:癌症;表觀遺傳學和核子訊號

Species Reactivity:老鼠;鼠

Reactivity:

Target Synonym:6 O 甲基鳥嘌呤 DNA 甲基轉移酶;6-O-甲基鳥嘌呤-DNA 甲基轉移酶;Agat;AGT;AI267024;EC 2.1.1.63;甲基化 DNA 蛋白半胱胺酸甲基轉移酶;甲基化-DNA-蛋白-半胱胺酸轉移酶;甲基鳥嘌呤 DNA 甲基轉移酶 MGC107020 6MT; O-6-甲基鳥嘌呤-DNA 甲基轉移酶;O-6-甲基鳥嘌呤-DNA-烷基轉移酶

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Buffer:含0.02％疊氮化鈉、1％保護蛋白和50％甘油的PBS，pH7.4

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Conjugation:未結合

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