庫存單位: E-BC-D003_96T-ES

基質金屬蛋白酶 3 (MMP-3) 抑制劑篩選試劑盒,96T

基質金屬蛋白酶3(MMP-3)是MMP家族的重要成員。 MMP-3前驅物被絲胺酸蛋白酶如纖溶酶、糜蛋白酶裂解,去除含有半胱胺酸開關的前驅勝肽,形成具有蛋白酶活性的MMP-3。 MMP-3可以降解或剪切多種細胞外基質成分、前驅蛋白或前驅酶,能夠破壞腫瘤細胞侵襲的組織學屏障,釋放E-cadherin,促進腫瘤侵襲和轉移,促進發炎反應,在腫瘤研究中受到越來越多的關注。此外,MMP-3也參與組織形態發生、損傷修復、發炎反應等一系列生理病理過程,在類風濕關節炎、動脈粥狀硬化等疾病的發生、發展中扮演重要角色。 本MMP-3抑制劑篩選試劑盒採用螢光共振能量轉移(FRET)方法進行檢測。 MCA和Dnp與MMP-3酶的天然底物的兩端相連。當MMP-3蛋白酶不裂解底物時,兩個基團足夠接近,發生螢光共振能量轉移,即Dnp可以猝滅MCA的螢光,導致檢測不到螢光。當底物被MMP-3蛋白酶切開後,多肽的兩端分離,兩個基團分離,MCA的螢光不再被Dnp熄滅,就可以檢測到MCA的螢光,因此可以透過螢光檢測很靈敏地檢測出MMP-3蛋白酶的酶活性。 若在反應體系中加入MMP-3蛋白酶抑制劑,則會抑制螢光的產生,且螢光強度與抑制劑的抑制效果成反比,可檢測出MMP-3蛋白酶抑制劑的抑制效果。 MCA的最大激發波長為325nm,最大發射波長為393nm。

定價
$705.60 USD
售價
$705.60 USD
定價
2-4 週內送達
Hassle-Free Warranty
Safe & Secure Payment
Livetime Tech Support
  • Specification
  • Downloads
  • Reviews
$705.60
ADD TO CART
ADD TO CART

Product Specification

Basic Information

Brands:Elabscience

Model Number:

Place of Origin:中國

Warranty:

Safety Performance:

Protection Class:

Sterile Status:

Reconstitution:

Shipping:冰袋

Battery:

Battery Service Life:

Component:

Technical Specifications

Capacity:

Concentration:

Dimension [D×W×H]:

Diameter:

Length:

Width:

High:

Volume:

Volume Range:

Speed:

Speed Range:

Max.Speed:

Max. RCF:

Temperature Range:

Operating Temperature Range:

Permissible Ambient Temperature :

Permissible Relative Humidity:

Input voltage:

Power Requirements:

Voltage/Frequency:

Sensitivity:

Specificity:

Precision:

Speed Accuracy:

Volume Accuracy:

Particle Size:

Pore Size:

Binding Capacity:

Calculated Molecular Weight:

Observed Molecular Weight:

Purity:

Shelf Life:12個月

Storage:本品在-20℃避光條件下可保存12個月。

Random Error:

Acceleration/Braking time:

Aspiration Speed:

Calculated Molecular Weight:

Dilution:

Driving Motor DC motor:

Em:

Ex:

Endotoxin:

Flow rate [liquid]:

Features and Capabilities

Application:

Detection Target:

Detection Type:螢光法

Detection Range:

Research Areas:抑制劑篩選

Species Reactivity:

Reactivity:

Target Synonym:基質金屬蛋白酶-3

Test Principle:

Quantitative/Qualitative :

Result Type:抑制率

Materials :

Assay Time:

Autoclave component:

Available Rotor Adapters:

Binding Capacity:

Bio-activity:

Bottom Shape:

Bottom Type:

Buffer:

Cap Color:

Clonality:

Conjugation:

Coupled Ligand:

Cover Type:

Detection Instrument :螢光微孔板讀數儀

Dispensing Speed:

Display:

Form:

Formulation:

Graduation:

Growth Area:

Download File