庫存單位: AN000090P_1mg-ES

Lipocalin-2/NGAL多克隆抗體(捕獲/檢測),1毫克

鐵運輸蛋白參與細胞凋亡、先天免疫和腎臟發育等多個過程。透過與 2,3-二羥基苯甲酸 (2,3-DHBA) 結合鐵,2,3-DHBA 是一種與細菌腸桿菌素具有結構相似性的鐵載體,並根據情況從細胞中輸送或去除鐵。鐵結合形式(holo-24p3)與SlC22A17(24p3R)受體結合後被內化,導致鐵的釋放,隨後細胞內鐵濃度的增加。相反,無鐵形式(apo-24p3)與SlC22A17(24p3R)受體結合後,會與細胞內的鐵載體結合,進行鐵螯合,並將鐵轉移到細胞外介質中,進而降低細胞內的鐵濃度。參與因白細胞介素-3(Il3)缺乏引起的細胞凋亡:載鐵形式增加細胞內鐵濃度而不促進細胞凋亡,而無鐵形式降低細胞內鐵水平,誘導促凋亡蛋白BCl2l11/BIM的表達,導致細胞凋亡。參與先天免疫,透過隔離與微生物鐵載體(如腸桿菌素)結合的鐵來限制細菌增殖。也可以結合結核分枝桿菌的鐵載體。

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Product Specification

Basic Information

Brands:Elabscience

Model Number:

Place of Origin:中國

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Shipping:產品隨附冰袋,收到後,請立即在建議的溫度下存放。

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Concentration:1毫克/毫升

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Shelf Life:12個月

Storage:4°C 下儲存有效期限為 12 個月,-20°C 下儲存有效期限為長期儲存,避免凍融循環。

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Dilution:ELISA 捕捉 2-8 μg/mL;ELISA 檢測 0.1-0.4 μg/mL

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Application:ELISA 擷取/檢測儀

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Research Areas:免疫學;心血管;訊號傳導;癌症;代謝

Species Reactivity:人類

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Target Synonym:LCN2;HNL;NGAL;中性粒細胞明膠酶相關脂質鈣蛋白;MMP-9 的 25 kDa α-2-微球蛋白相關亞基;脂質鈣蛋白-2;致癌基因 24p3;鐵鈣蛋白;p25

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Buffer:磷酸鹽緩衝溶液,pH 值為 7.2,含 0.05% proclin 300。

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Clonality:多克隆

Conjugation:未結合

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