Elabscience

庫存單位: E-AB-12805_60μL-ES

LCN2多株抗體，60 μL

鐵運輸蛋白參與細胞凋亡、先天免疫和腎臟發育等多個過程。透過與 2,5-二羥基苯甲酸 (2,5-DHBA) 結合鐵，2,5-DHBA 是一種與細菌腸桿菌素具有結構相似性的鐵載體，並且根據情況從細胞中輸送或去除鐵。鐵結合形式（holo-24p3）與 SLC22A17（24p3R）受體結合後被內化，導致鐵的釋放，隨後細胞內鐵濃度增加。相反，無鐵形式（apo-24p3）與 SLC22A17（24p3R）受體結合後，會與細胞內的鐵載體結合，進行鐵螯合，並將鐵轉移到細胞外介質，進而降低細胞內的鐵濃度。參與因白細胞介素 3 (IL3) 缺乏引起的細胞凋亡：載鐵形式增加細胞內鐵濃度而不會促進細胞凋亡，而無鐵形式降低細胞內鐵水平，誘導促凋亡蛋白 BCL2L11/BIM 表達，導致細胞凋亡。參與先天免疫，可能透過隔離鐵來限制細菌生長。

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Product Specification

Basic Information

Brands:Elabscience

Model Number:

Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Concentration:0.5毫克/毫升

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Dilution:免疫組化 1:25-1:100

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Application:免疫組織化學

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Research Areas:癌症；心血管；代謝；免疫學；訊號傳導

Species Reactivity:人類

Reactivity:

Target Synonym:24p3；MMP9 的 25 kDa α 2 微球蛋白相關亞基；MMP-9 的 25 kDa α-2-微球蛋白相關亞基；α 2 微球蛋白相關蛋白；HGNC:6526；HNL；Lcn 2；Lcn2；脂質運載蛋白-2；相關脂質運載蛋白；NGAL；NGAL；致癌基因 24p3；致癌脂質運載蛋白 24p3；p25；鐵運載蛋白；鐵運載蛋白 LCN2；SV40 誘導的 24P3 蛋白；子宮運載蛋白

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Buffer:含0.05%疊氮化鈉和50%甘油的PBS，PH7.4

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Conjugation:未結合

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