Elabscience

庫存單位: E-AB-62227_60μL-ES

（KO 驗證）STAT3 多克隆抗體，60 μL

此基因編碼的蛋白質是 STAT 蛋白家族的成員。在細胞激素和生長因子的作用下，STAT 家族成員被受體相關激酶磷酸化，然後形成同二聚體或異二聚體，轉移到細胞核中，在那裡充當轉錄激活因子。此蛋白質透過磷酸化激活，響應各種細胞因子和生長因子，包括 IFN、EGF、IL5、IL6、HGF、LIF 和 BMP2。這種蛋白質介導細胞對刺激作出反應的多種基因的表達，從而在細胞生長和細胞凋亡等許多細胞過程中發揮關鍵作用。小 GTPase Rac1 已被證明能夠結合併調節這種蛋白質的活性。 PIAS3蛋白是該蛋白質的特定抑制劑。此基因的突變與嬰兒期發病的多系統自體免疫疾病和高免疫球蛋白 E 症候群有關。可變剪接產生編碼不同亞型的多個轉錄變異。

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Product Specification

Basic Information

Brands:Elabscience

Model Number:

Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Concentration:1毫克/毫升

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Calculated Molecular Weight:83kDa/87kDa/88kDa

Observed Molecular Weight:90kDa

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Calculated Molecular Weight:83kDa/87kDa/88kDa

Dilution:廣譜 1:500-1:2000；中和 1:50-1:200

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Application:世銀；如果

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Research Areas:癌症；心血管；表觀遺傳學和核子訊號；發育生物學；訊號傳導；幹細胞

Species Reactivity:人類;小鼠;大鼠

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Buffer:含 0.02% 疊氮化鈉、50% 甘油的 PBS，pH7.3。

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Clonality:多克隆

Conjugation:未結合

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