Elabscience

庫存單位: E-AB-16691_120μL-ES

KDM4B 多株抗體，120 μL

JMJD2B（含JmjC結構域的組蛋白去甲基化蛋白3A）是由人類基因JMJD2B編碼的1,064個胺基酸的蛋白質。 JMJD2B 屬於 JMJD2B 組蛋白去甲基化酶家族，含有一個 JmjC 結構域、一個 JmjN 結構域、兩個 PHD 型鋅指和兩個 Tudor 結構域。兩個Tudor結構域能夠識別並結合甲基化的組蛋白，並且具有交錯結構；這種不尋常的折疊是其與甲基化組蛋白尾結合所必需的。 JMJD2B是一種組蛋白去甲基化酶，能夠特異性地對組蛋白H3的Lys9殘基進行去甲基化，從而在組蛋白密碼中發揮作用。然而，它不能去甲基化組蛋白 H3 Lys 4、H3 Lys 27、H3 Lys 36 或 H4 Lys 20，只能去甲基化三甲基化的 H3 Lys-9，且活性比 JMJD2A、JMJD2C 和 JMJD2D 弱。 JMJD2B 賴氨酸殘基去甲基化會生成甲醛和琥珀酸。 JMJD2B 是一種普遍表現的核蛋白。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Concentration:1毫克/毫升

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Dilution:免疫組化 1:50-1:200

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Application:免疫組織化學

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Research Areas:癌症；表觀遺傳學和核子訊號傳導

Species Reactivity:人類

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Target Synonym:JHDM3B；含有 JmjC 結構域的組蛋白去甲基化蛋白 3B；JMJD2B；含有 Jumonji 結構域的 2B；含有 Jumonji 結構域的蛋白質 2B；含有 Jumonji 結構域的蛋白質 2B；Kdm4b；KDM4B；KIAA0876 賴氨酸 (KTDB4)； 4B；含有 Tudor 結構域的 14B

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Buffer:含0.05%疊氮化鈉和50%甘油的PBS，PH7.4

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Conjugation:未結合

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