庫存單位: E-AB-22189_60μL-ES

HIF1 bata 單株抗體,60 μL

缺氧誘導因子 1 (HIF1) 是一種異二聚體轉錄因子,在細胞對缺氧的反應中扮演關鍵角色 (1)。 HIF1 複合物由兩個亞基 HIF-1α 和 HIF-1β 組成,它們是 PAS(Per、ARNT、Sim)家族 (2) 的鹼性螺旋-環-螺旋蛋白。 HIF1 調節多種基因的轉錄,促進對缺氧環境的反應,包括調節血管生成、紅血球生成、細胞週期、代謝和細胞凋亡的基因。廣泛表達的 HIF-1α 通常在常氧細胞中透過泛素/蛋白酶體途徑快速降解。在常氧條件下,HIF-1α 被脯胺酸羥基化,導致構象變化,促進與馮·希佩爾·林道蛋白 (VLH) E3 連接酶複合物的結合;隨後發生泛素化和蛋白酶體降解(3,4)。缺氧條件和化學羥化酶抑制劑(如去鐵胺和鈷)均可抑制 HIF-1α 降解並使其穩定化。此外,各種細胞激素可以透過 PI3K-AKT-mTOR 路徑 (5-7) 以氧非依賴的方式誘導 HIF-1α。 HIF-1β 也稱為 AhR 核轉運蛋白 (ARNT),因為它能夠與芳香烴受體 (AhR) 結合形成異二聚體轉錄因子複合物 (8)。 HIF-1β 與 AhR 一起在外來化合物代謝中發揮重要作用 (8)。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Shipping:產品隨附冰袋,收到後,請立即在建議的溫度下存放。

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Concentration:1毫克/毫升

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Observed Molecular Weight:87kDa

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Shelf Life:12個月

Storage:儲存於-20°C,有效期限為12個月。避免凍融循環。

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Dilution:免疫印跡 1:1000~2000

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Application:WB;IHC-p;IF

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Research Areas:癌症;心血管;表觀遺傳學和核子訊號;代謝

Species Reactivity:老鼠

Reactivity:

Target Synonym:arnT;ARNT 蛋白;ARNT;芳烴受體核轉運蛋白;bHLHe2;E 類鹼性螺旋-環-螺旋蛋白 2;二噁英受體;二噁英受體核轉運蛋白;Drnt;HIF 1 beta;HIF 1beta;HIF-1-beta;HIF1-betaHIF1B;HIFHIF1B;HIF1-beta;HIF1-betaHIF1B;HIFH11B;HIF1-beta;HIF1-betaHIF1B;H11HIF1B;H11-beta1B;

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Buffer:含0.02%疊氮化鈉、0.5%保護蛋白和50%甘油的PBS,pH7.4

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Conjugation:未結合

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