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庫存單位: E-AB-67390_60μL-ES
GPX4 多克隆抗體，60 μL
此基因編碼的蛋白質屬於穀胱甘肽過氧化物酶家族，該家族成員可催化過氧化氫、有機氫過氧化物和脂質氫過氧化物的還原，從而保護細胞免受氧化損傷。脊椎動物中存在該基因家族的幾種同工酶，它們的細胞位置和底物特異性各不相同。此同功酶對脂質氫過氧化物有很高的偏好性，可以保護細胞免受膜脂質過氧化和細胞死亡。它也是精子正常發育所必需的；因此，由於它具有過氧化物酶和成熟精子結構蛋白的雙重功能，因此被認定為「兼職」蛋白。此基因突變與 Sedaghatian 型脊椎幹骺端發育不良 (SMDS) 有關。此同功酶也是一種硒蛋白，其活性位點含有稀有氨基酸硒代半胱氨酸 (Sec)。 Sec 由 UGA 密碼子編碼，通常表示翻譯終止。硒蛋白 mRNA 的 3' UTR 含有保守的莖環結構，稱為 Sec 插入序列 (SECIS) 元素，這是將 UGA 識別為 Sec 密碼子而不是終止訊號所必需的。已發現該基因的剪接轉錄變異體。
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:中國
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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。
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Concentration:1毫克/毫升
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Calculated Molecular Weight:19kDa/22kDa
Observed Molecular Weight:22KDa
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Shelf Life:12個月
Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。
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Calculated Molecular Weight:19kDa/22kDa
Dilution:廣譜 1:500-1:2000；中和 1:50-1:200
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Features and Capabilities
Application:世銀；如果
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Research Areas:癌症;代謝;訊號傳導
Species Reactivity:人類;老鼠;鼠
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Target Synonym:GPX4；GPx-4；GSHPx-4；MCSP；PHGPx；SMDS；snGPx；snPHGPx
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Buffer:PBS含0.05％proclin300、50％甘油，pH7.3。
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Clonality:多克隆
Conjugation:未結合
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