Elabscience

庫存單位: E-AB-12603_200μL-ES

GluR2多株抗體，200 μL

麩胺酸受體是哺乳動物大腦中主要的興奮性神經傳導物質受體，在多種正常的神經生理過程中被活化。此基因產物屬於谷氨酸受體家族，對α-氨基-3-羥基-5-甲基-4-異噁唑丙酸酯 (AMPA) 敏感，並作為配體活化的陽離子通道發揮作用。這些通道由 4 個相關亞基 GRIA1-4 組裝而成。此基因（GRIA2）編碼的亞基在第二個跨膜結構域內受到RNA編輯（CAG->CGG; Q->R），被認為使得通道不滲透Ca（2+）。人類和動物研究表明，前 mRNA 編輯對於大腦功能至關重要，而 Q/R 位點的 GRIA2 RNA 編輯缺陷可能與肌萎縮側索硬化症 (ALS) 病因有關。已經注意到該基因具有可變剪接，從而產生編碼不同異構體的轉錄變體（包括訊號傳導特性各異的翻轉和突變異構體）。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Concentration:0.4 毫克/毫升

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Dilution:免疫組化 1:25-1:100

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Application:免疫組織化學

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Research Areas:癌症；神經科學

Species Reactivity:人類;小鼠;大鼠

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Target Synonym:AMPA 2；AMPA 選擇性麩胺酸受體 2；AMPA 選擇性麩胺酸受體 2；AMPA2；GluA2；GLUR 2；GLUR B；GluR K2；GluR-2；GluR-B；GluR-K2；GLUR2；GLURB；谷氨酸受體 2；麩胺酸受體離子型 AMPA 2；麩胺酸離子型；

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Buffer:含0.05%疊氮化鈉和50%甘油的PBS，PH7.4

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Clonality:多克隆

Conjugation:未結合

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