庫存單位: E-AB-10356_200μL-ES

ERG多株抗體,200 μL

此基因編碼紅血球轉化特異性(ETS)轉錄因子家族的一個成員。該家族的所有成員都是胚胎發育、細胞增殖、分化、血管生成、發炎和細胞凋亡的關鍵調節器。此基因編碼的蛋白質主要在細胞核中表現。它包含一個 ETS DNA 結合域和一個 PNT(尖銳)域,與嵌合癌蛋白的自我結合有關。這種蛋白質是血小板黏附在內皮下所必需的,可誘導血管細胞重塑。它還調節造血以及巨核細胞的分化和成熟。此基因參與染色體易位,導致不同的融合基因產物,如前列腺癌中的TMPSSR2-ERG和NDRG1-ERG,尤文氏肉瘤中的EWS-ERG和急性髓系白血病中的FUS-ERG。已經鑑定出多種編碼不同亞型的剪接轉錄變異體。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Shipping:產品隨附冰袋,收到後,請立即在建議的溫度下存放。

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Concentration:0.3 毫克/毫升

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Shelf Life:12個月

Storage:儲存於-20°C,有效期限為12個月。避免凍融循環。

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Dilution:免疫組化 1:25-1:100

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Application:免疫組織化學

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Research Areas:癌症;表觀遺傳學和核子訊號;幹細胞

Species Reactivity:人;小鼠

Reactivity:

Target Synonym:禽科紅血球增多症病毒 E-26 (v-ets) 致癌基因相關;D030036I24Rik;Erg 3;Erg;ERG/EWS 融合基因;包括;ERG/FUS 融合基因;包括;ERG/TMPSSR2 融合基因;包括ERG;ERG/FUS 融合基因;包括;ERG/TMPSSR2 融合基因;包括ERG; /ERG 融合;轉錄調節因子 ERG (轉化蛋白 ERG);轉錄調節因子 ERG;轉化蛋白 ERG;v ets 禽科紅血球增多症病毒 E26 致癌基因;v ets 禽科紅血球增多症病毒 E26 致癌基因相關;v ets 紅血球增多症病毒 Ev26 致癌基因同源物;致癌基因樣異構體 2;v-ets 紅血球增多症病毒 E26 致癌基因;v-ets 紅血球增多症病毒 E26 致癌基因同源物 (禽類);V-ets 紅血球增多症病毒 E26 致癌基因樣 (禽類);異構體 CRA_e

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Buffer:含0.05%疊氮化鈉和50%甘油的PBS,PH7.4

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Conjugation:未結合

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