Elabscience

庫存單位: E-AB-31291_20μL-ES

EGFR多株抗體，20 μL

受體酪胺酸激酶結合 EGF 家族的配體並活化多個訊號級聯，將細胞外訊號轉化為適當的細胞反應。已知的配體包括 EGF、TGFA/TGF-alpha、雙調蛋白、epigen/EPGN、BTC/betacellulin、epiregulin/EREG 和 HBEGF/肝素結合 EGF。配體結合觸發受體同源性和/或異源二聚化以及關鍵細胞質殘基的自身磷酸化。磷酸化受體募集 GRB2 等銜接蛋白，進而活化複雜的下游訊號級聯。活化至少 4 個主要下游訊號級聯，包括 RAS-RAF-MEK-ERK、PI3 激酶-AKT、PLCgamma-PKC 和 STATs 模組。也可能活化 NF-kappa-B 訊號級聯。也直接磷酸化其他蛋白質如 RGS16，活化其 GTPase 活性，並可能將 EGF 受體訊號與 G 蛋白偶聯受體訊號偶聯。也磷酸化 MUC1 並增加其與 SRC 和 CTNNB1/beta-catenin 的相互作用。異構體 2 可能充當 EGF 作用的拮抗劑。

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Product Specification

Basic Information

Brands:Elabscience

Model Number:

Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Concentration:1毫克/毫升

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Calculated Molecular Weight:134kDa

Observed Molecular Weight:134kDa

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Calculated Molecular Weight:134kDa

Dilution:WB 1:500-1:2000；IHC 1:100-1:300；IF 1:200-1:1000

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Application:WB;IHC-p;IF

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Research Areas:癌症；訊號傳導

Species Reactivity:人類;小鼠;大鼠

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Target Synonym:禽類紅血球白血病病毒 (v erb b) 致癌基因同源物;細胞生長抑制蛋白 40;細胞增殖誘導蛋白 61;EGF R;EGFR;EGFR;表皮生長因子受體（禽類紅血球白血病病毒 (v erb b) 致癌基因同源物）；表皮生長因子受體（禽類紅血球白血病病毒 (v erb b) 致癌基因同源物）；表皮生長因子受體（禽類紅細胞白血病病毒 (vberbER) 磷酸激酶； ；HER1；mENA；NISBD2；致癌基因 ERBB；PIG61；原癌基因 c-ErbB-1；受體酪胺酸蛋白激酶 ErbB 1；受體酪胺酸蛋白激酶 ErbB-1；SA7；物種抗原7;Urogastrone;v-erb-b 禽紅血球白血病病毒致癌基因同源物;wa2;Wa5同源物;

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Buffer:含0.02％疊氮化鈉、0.5％保護蛋白和50％甘油的PBS，pH7.4

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Clonality:多克隆

Conjugation:未結合

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