Elabscience

庫存單位: E-AB-22111_200μL-ES

連環蛋白β單株抗體，200μL

經典 Wnt 訊息傳遞路徑的關鍵下游成分。在沒有 Wnt 的情況下，與 AXIN1、AXIN2、APC、CSNK1A1 和 GSK3B 形成複合物，促進 N 端 Ser 和 Thr 殘基的磷酸化以及透過 BTRC 實現 CTNNB1 的泛素化，隨後被蛋白酶體降解。在Wnt配體存在的情況下，CTNNB1不會被泛素化並在細胞核中積累，在那裡它作為TCF/LEF家族轉錄因子的輔激活因子，從而激活Wnt反應基因。參與細胞黏附的調節。大部分 β-catenin 位於細胞膜上並且是 E-cadherin/catenin 黏附複合物的一部分，該複合物負責將鈣黏蛋白與肌動蛋白細胞骨架偶聯。

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Product Specification

Basic Information

Brands:Elabscience

Model Number:

Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Concentration:1毫克/毫升

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Observed Molecular Weight:92kDa

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Dilution:WB 1:500-1:2000；IHC 1:100-1:300；IF 1:100-1:300

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Application:WB;IHC-p;IF

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Research Areas:癌症；心血管；神經科學；訊號傳導；幹細胞

Species Reactivity:人類;小鼠;大鼠

Reactivity:

Target Synonym:β-連環蛋白；β-連環蛋白；鈣粘蛋白相關蛋白；連環蛋白（鈣粘蛋白相關蛋白）；β 1；88kDa；連環蛋白β 1；連環蛋白β-1；CATNB；CHBCAT；CTNB1；CTNNB；CTNNB1；DKFZp686D022532J256020202020202025；PFL UMP00000165222；OTTHUMP00000165223；OTTHUMP00000209288；OTTHUMP00000209289

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Buffer:含有 0.02% 疊氮化鈉和 50% 甘油的 PBS，pH 值為 7.4。

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Conjugation:未結合

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