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庫存單位: E-AB-22107_200μL-ES
CASP8單株抗體，200 μL
負責 TNFRSF6/FAS 介導和 TNFRSF1A 誘導的細胞死亡的胱天蛋白酶活化級聯的最上游蛋白酶。與銜接分子 FADD 結合會將其募集至任一受體。由此產生的聚集體稱為死亡誘導訊號複合物 (DISC)，它執行 CASP8 蛋白水解活化。然後，活性二聚體酶從 DISC 中釋放出來，並自由活化下游的凋亡蛋白酶。 N 端前肽的蛋白水解片段（稱為 CAP3、CAP5 和 CAP6）可能保留在 DISC 中。切割並活化 CASP3、CASP4、CASP6、CASP7、CASP9 和 CASP10。可能參與GZMB細胞凋亡途徑。劈開 ADPRT。水解小分子底物 Ac-Asp-Glu-Val-Asp-AMC。可能是牛痘病毒 CRMA 死亡抑制蛋白的標靶。異構體 5、異構體 6、異構體 7 和異構體 8 缺乏催化位點，可能會幹擾複合物的促凋亡活性。
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:中國
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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。
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Concentration:1毫克/毫升
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Observed Molecular Weight:43,57kDa
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Shelf Life:12個月
Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。
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Dilution:WB 1:500-1:2000；IHC 1:100-1:300；IF 1:100-1:300
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Application:WB;IHC-p;IF
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Research Areas:癌症；細胞生物學；代謝
Species Reactivity:人類;小鼠;大鼠
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Target Synonym:ALPS2B；肌萎縮側索硬化症 2 染色體區域候選基因 12 蛋白；凋亡半胱氨酸蛋白酶；凋亡蛋白酶 Mch-5；凋亡蛋白酶 Mch5；CAP4；CASP-8；CASP8；CASP8；胱天蛋白酶 8；胱天蛋白酶 8 凋亡相關半胱氨酸FAICE 類蛋白酶； FLJ17672；ICE 類凋亡蛋白酶 5；MACH alpha 1/2/3 蛋白；MACH；MACH beta 1/2/3/4 蛋白；MCH5；MGC78473；MORT1 相關 ced 3 同源物；MORT1 相關 CED-3同源物；OTTHUMP00000163717；OTTHUMP00000163720；OTTHUMP00000163724；OTTHUMP00000163725；OTTH UMP00000165062；OTTHUMP00000165063；OTTHUMP00000165064；OTTHUMP00000206552；OTTHUMP00000206582
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Buffer:含有 0.02% 疊氮化鈉和 50% 甘油的 PBS，pH 值為 7.4。
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Clonality:單複製
Conjugation:未結合
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