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庫存單位: E-AB-17827_60μL-ES
ACER1多株抗體，60 μL
ACER1（鹼性神經醯胺酶 1）是一種蛋白質編碼基因。與 ACER1 相關的疾病包括角膜營養不良、後部無定形。其相關途徑包括鞘脂代謝和鞘脂訊號路徑。與此基因相關的 GO 註釋包括作用於碳氮（而不是勝肽）鍵、線性醯胺的水解酶活性和二氫神經醯胺酶活性。此基因的一個重要的旁系同源物是ACER2。神經醯胺是在表皮分化過程中合成的，並積聚在角質層間隙內，它們是表皮通透性屏障的關鍵組成部分。細胞中過量的神經醯胺可以觸發抗有絲分裂訊號並誘導細胞凋亡，而神經醯胺代謝物鞘氨醇和鞘氨醇-1-磷酸 (S1P) 是重要的生物調節分子。有核細胞層中的神經酰胺水解調節角質形成細胞增殖和凋亡以響應外界壓力。神經醯胺水解也發生在角質層，釋放出遊離的鞘氨醇鹼，可作為內源性抗菌劑。 ACER1 在表皮中高度表達，並催化超長鏈神經醯胺的水解生成鞘氨醇。
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:中國
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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。
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Concentration:1.2 毫克/毫升
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Shelf Life:12個月
Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。
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Dilution:免疫組化 1:40-1:200
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Application:免疫組織化學
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Research Areas:癌症；代謝；訊號傳導
Species Reactivity:人類
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Target Synonym:宏碁1；宏碁1；酰基鞘氨醇脫酰酶3；鹼性胞嘧啶脫氨酶1；鹼性神經醯胺酶1；鹼性神經醯胺酶；鹼性磷酸酶1； ALKCDase1； ASAH 3； ；N-酰基鞘氨醇醯胺水解酶3
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Buffer:含 0.05% NaN3 和 40% 甘油的 PBS，pH7.4
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Clonality:多克隆
Conjugation:未結合
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