Elabscience

庫存單位: E-BC-F076_48T-ES

β-分泌酶 1 (BACE 1) 活性螢光測定試劑盒，48T

β-分泌酶1是一種天門冬胺酸蛋白酶，全名是β位澱粉樣蛋白前體裂解酶1（BACE 1）。 BACE 1 裂解澱粉樣蛋白前驅物 (APP)，產生 40 或 42 個胺基酸的澱粉樣蛋白-β 勝肽 (Aβ)。一般認為，阿茲海默症患者腦內斑塊和血管壁中 Aβ 的沉積是導致此疾病的主要因素。 本試劑盒的檢測原理為螢光共振能量轉移（FRET）方法。底物的兩端分別有一個螢光供體基團和一個猝滅基。螢光能量從螢光供體轉移到猝滅基團上，導致螢光供體分子本身螢光強度的衰減。當底物被BACE 1酶切後，底物上的猝滅基團與螢光供體的猝滅基團分離，螢光供體的螢光不再被猝滅，就可以檢測到螢光供體的螢光，從而計算出BACE 1的酶活性。此試劑盒產生的螢光最大激發波長為325nm,最大吸收波長為393nm。

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Product Specification

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Brands:Elabscience

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Place of Origin:中國

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Sensitivity:0.003單位/公升

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Shelf Life:12個月

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Detection Type:螢光法

Detection Range: 0.003-4.75單位/公升

Research Areas:胺基酸和蛋白質

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Target Synonym:巴克萊 1

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Result Type:酵素活性

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Detection Instrument :螢光微孔板讀數儀

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