Elabscience

庫存單位: AN005930L_100μL-ES

TNF RI/TNFRSF1A 多克隆抗體，100 μL

TNF-α 是一種重要的細胞因子，由多種細胞類型產生，包括嗜中性球、活化淋巴球、巨噬細胞和 NK 細胞。它在發炎反應和細胞凋亡中起著關鍵作用。 TNF-α以膜錨定和可溶性形式存在，均具有生物活性。 TNF-α 的反應由兩種受體介導，即廣泛表達的 TNF-R1 和主要在免疫細胞和內皮細胞中表達的 TNF-R2。 TNF-α 拮抗劑已被證實是類風濕性關節炎和其他免疫疾病的治療標靶。 TNF-α 的兩種受體 TNF-R1 (55 kDa) 和 TNF-R2 (75 kDa) 可以介導不同的細胞反應。據報導，在大多數情況下，TNF 引起的細胞毒性是透過 TNF-R1 起作用的。細胞毒性是由受體胞內區域的「死亡結構域」介導的，該結構域與死亡結構域銜接蛋白 TRADD 結合，並觸發胱天蛋白酶的活化 (8)。這兩種受體的可溶性形式也已被證實可以結合 TNF-α，並可能在免疫疾病中發揮重要作用。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Shipping:產品隨附冰袋，收到後請立即在建議的溫度下存放。

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Concentration:1毫克/毫升

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Calculated Molecular Weight:50千道爾頓

Observed Molecular Weight:50千道爾頓

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為 12 個月。避免凍融循環。避免長時間暴露於光線下。

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Application:世界銀行

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Species Reactivity:人類;大鼠

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Target Synonym:CD120a;FPF;MS5;p55-R;p60;TBP1;TNFAR;TNFR1;TNFR1-d2;TNFR55;TNF-R55;TNFR60;TNF-RI;TBP;TNFα-R;TNF-αR;TNFRpTNFRFR1-dFPFSn; ;TBP1;TNFα-R1;TNF-αR1;TNFAR;Tnfr;TNF-R;TNF-R1;TNFR1-d2;TNFR55;TNF-R55;TNFR60;TNFRI;TNF-RI;TNFRp55;TNFn-1;TTNFR60;TNFRI;TNF-RI;TNFRp55;Tn-1;TFRnfra.

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Buffer:含0.02％疊氮化鈉、1％保護蛋白和50％甘油的PBS，pH7.4

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Clonality:多克隆

Conjugation:未結合

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