Elabscience

庫存單位: E-AB-12636_20μL-ES

SHH多株抗體，20 μL

此基因編碼的蛋白質對早期胚胎的形態形成有重要作用。它被認為是腹側神經管、前後肢軸和腹側體節模式形成的關鍵誘導訊號。在三種與果蠅音蝟蛋白具有序列和功能相似性的人類蛋白質中，此蛋白質最為相似。該蛋白質是以自催化裂解的前體形式製成的； N端部分可溶且包含信號活性，而C端部分參與前體處理。更重要的是，C 端產物與 N 端產物共價連接膽固醇部分，將 N 端產物限制在細胞表面，並阻止其在整個發育胚胎中自由擴散。這種蛋白質或其訊號路徑的缺陷是全前腦畸形 (HPE) 的原因，這種疾病是指發育中的前腦無法正確分為左右半球。 HPE的表現是臉部畸形。人們還認為，該基因或其信號通路的突變可能是導致 VACTERL 綜合徵的原因，該綜合徵的特徵是脊椎缺損、肛門閉鎖、伴有食道閉鎖的氣管食道瘺、橈骨和腎發育不良、心臟異常以及肢體異常。

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Product Specification

Basic Information

Brands:Elabscience

Model Number:

Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Concentration:0.5毫克/毫升

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Dilution:免疫組化 1:50-1:200

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Application:免疫組織化學

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Research Areas:癌症；表觀遺傳學和核子訊號；代謝；發育生物學；幹細胞

Species Reactivity:人類;小鼠;大鼠

Reactivity:

Target Synonym:HHG 1；HHG-1；HHG1；HLP 3；HLP3；Holoprosencephaly 3；HPE 3；HPE3；MCOPCB5；shh；SHH；SMMC I；SMMCI；Sonic Hedgehog（果蠅）同源物；Sonic Hedgehog 同源物（Hedgeg 組）；Sonic Hedgehog（SedgegTPSedgeg]g Hedgeg；

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Buffer:含0.05%疊氮化鈉和50%甘油的PBS，PH7.4

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Clonality:多克隆

Conjugation:未結合

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