Elabscience

庫存單位: E-AB-13295_60μL-ES

HMGCS1多株抗體，60 μL

HMG-CoA 合成酶既存在於粒線體 (mHMGCS) 中，也存在於細胞質 (cHMGCS) 中，它將乙醯輔酶 A 與乙醯乙醯輔酶 A 縮合形成 HMG-CoA。 cHMGCS 產生的 HMG-CoA 在 HMG-CoA 還原酶的作用下轉化為甲羥戊酸，從而啟動異戊二烯的生物合成。異戊二烯途徑的最終產物包括膽固醇、泛醌、多萜醇、異戊烯基腺苷和法呢基。 mHMGCS 與 HMG-CoA 裂解酶一起負責酮體的生物合成。 mHMGCS在肝臟和腎臟中表現。禁食、cAMP 和脂肪酸會增加 mHMGCS 的轉錄水平，而進食和胰島素則會抑制它。 mHMGCS 啟動子內的調控元件透過 PPAR、RXR、COUP-TF 和 HNF-4 提供轉錄調控。

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:中國

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Shipping:產品隨附冰袋，收到後，請立即在建議的溫度下存放。

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Concentration:0.4 毫克/毫升

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Calculated Molecular Weight:57kDa

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Shelf Life:12個月

Storage:儲存於-20°C，有效期限為12個月。避免凍融循環。

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Calculated Molecular Weight:57kDa

Dilution:免疫印跡法 1:500-1:2000

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Application:免疫組化

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Research Areas:癌症；心血管；代謝；訊號傳導

Species Reactivity:人類

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Target Synonym:3 羥基 3 甲基戊二酰輔酶 A 合成酶 1（可溶）；3-羥基-3-甲基戊二酰輔酶 A 合成酶；細胞質；EC 2.3.3.10；HMCS1；HMG CoA 合成酶；HMG-CoA 合成酶；HMGCS HMGCS1；羥基羥基合成酶 3935 二輔酶二二酰二二酰二二酰二二酰酶 ；

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Buffer:含0.05%疊氮化鈉和50%甘油的PBS，PH7.4

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Clonality:多克隆

Conjugation:未結合

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